Studies on RNA isolation continue without slowing down today. Although the results obtained with the RNA isolation method known as Trizol or TRI Reagent in 1987 for the first time, provided high efficiency, this process took a long time and was based on the use of some harmful organic solutions. In the following years, total RNA isolation kits based on silica-based spin column method started to attract people’s attention. Although harmful components such as phenol were not required in kits based on this method, the isolated RNA obtained with these kits was generally longer than 200 nucleotides and small RNAs were excluded from the process. Although the desired results are achieved, all these methods continue to be time-consuming and contain harmful chemicals. For this reason, a harmless and fast isolation method was needed to cover all RNA types and Norgen has made one of the latest innovations in this field. It comes up with its Silicon Carbide-based method. Norgen’s Silicon Carbide technology is differentiating from their rivals by broad spectrum of RNA binding, high sensivity, carrier RNA-free extraction, phenol / chloroform-free extraction, and virus inactivation.