A new study reveals the surprising role of NEAT1(Nuclear Paraspeckle Assembly Transcript 1) in maintaining the genetic integrity of cells and provides a whole new perspective on the #DNA damage response.
NEAT1 gene transcripts are overexpressed in many tumors and respond to genotoxic stress. However, the mechanism linking NEAT1 to DNA damage response remains unclear. In this study;
The effects of DNA double-strand breaks (DSBs) on genome stability allow us to better understand the role of NEAT1 in the DNA damage response (DDR). Research shows that DNA damage increases NEAT1 levels and N6-methyladenosine (m6A) signaling. This process triggers changes in NEAT1 structure and promotes NEAT1 accumulation at promoter-associated DSBs and DSB signaling.
NEAT1 depletion increases DNA damage by inhibiting DSB foci formation. Through RNA methylation provided by METTL3, NEAT1 interaction with the chromodomain helicase DNA binding protein 4 (CHD4) enhances the DDR mechanism by fine-tuning histone acetylation.
https://genesdev.cshlp.org/content/38/17-20/915
These findings emphasize the genome-protective role of NEAT1 under genotoxic stress.
NEAT1 plays a critical role in promoting the DNA damage response (DDR) under genotoxic stress. It maintains genome stability by promoting structural changes and DSB signaling through m6A methylation.
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